Progesterone receptor is involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin-stimulated breast cancer cells proliferation

Yun-Ju Chen; Chao-Ming Hung; Nari Kay; Chin-Chen Chen; Ying-Hsien Kao; Shyng-Shiou Yuan

doi:10.1016/j.canlet.2012.01.017

Progesterone receptor is involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin-stimulated breast cancer cells proliferation

Cancer Lett. 2012 Jun 28;319(2):223-231. doi: 10.1016/j.canlet.2012.01.017. Epub 2012 Jan 18.

Authors

Yun-Ju Chen¹, Chao-Ming Hung², Nari Kay³, Chin-Chen Chen³, Ying-Hsien Kao⁴, Shyng-Shiou Yuan⁵

Affiliations

¹ Department of Biological Science and Technology, I-Shou University, Kaohsiung 824, Taiwan, ROC; Department of Medical Research, E-DA Hospital, I-Shou University, Kaohsiung 824, Taiwan, ROC.
² Department of General Surgery, E-DA Hospital, Kaohsiung 824, Taiwan, ROC.
³ Department of Obstetrics and Gynecology, E-DA Hospital, Kaohsiung 824, Taiwan, ROC.
⁴ Department of Medical Research, E-DA Hospital, I-Shou University, Kaohsiung 824, Taiwan, ROC.
⁵ Department of Biological Science and Technology, I-Shou University, Kaohsiung 824, Taiwan, ROC; Department of Obstetrics and Gynecology, E-DA Hospital, Kaohsiung 824, Taiwan, ROC; Department of Medical Research, E-DA Hospital, I-Shou University, Kaohsiung 824, Taiwan, ROC. Electronic address: yuanssf@ms33.hinet.net.

PMID: 22266097
DOI: 10.1016/j.canlet.2012.01.017

Abstract

Sex hormones are pivotal for both normal and neoplastic development of breast tissues. TCDD, with sex hormonal activity, executes multiple biological activities primarily through AhR. However, the detailed mechanisms how TCDD affects human breast cell are mostly unexplored. We analyzed the biological effects and underlying mechanisms of TCDD on MCF-7 cells. PR, other than AhR, was involved in TCDD-stimulated MCF-7 cell proliferation. TCDD inactivated Akt-FoxO3a pathway, increased cdc25C/cdc2 activity, decreased P21/P27 activity, and enriched G2/M phase, in a PR- and AhR-dependent manner. In conclusion, our study demonstrated for the first time that PR was involved in TCDD-stimulated breast cell proliferation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Breast Neoplasms / chemically induced
Breast Neoplasms / genetics*
Breast Neoplasms / metabolism
Carcinogens / toxicity*
Cell Cycle / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Female
Humans
Polychlorinated Dibenzodioxins / toxicity*
Receptors, Progesterone / genetics*
Signal Transduction / drug effects

Substances

Carcinogens
Polychlorinated Dibenzodioxins
Receptors, Progesterone