Abstract
Emerging evidence indicates that RUNX3 is a tumor suppressor in breast cancer. RUNX3 is frequently inactivated in human breast cancer cell lines and cancer samples by hemizygous deletion of the Runx3 gene, hypermethylation of the Runx3 promoter, or cytoplasmic sequestration of RUNX3 protein. Inactivation of RUNX3 is associated with the initiation and progression of breast cancer. Female Runx3(+/-) mice spontaneously develop ductal carcinoma, and overexpression of RUNX3 inhibits the proliferation, tumorigenic potential, and invasiveness of breast cancer cells. This review is intended to summarize these findings and discuss the tumor suppressor function of RUNX3 in breast cancer.
Copyright © 2012 Wiley Periodicals, Inc.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Biological Transport, Active
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Breast Neoplasms / genetics*
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Breast Neoplasms / physiopathology*
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Core Binding Factor Alpha 3 Subunit / deficiency
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Core Binding Factor Alpha 3 Subunit / genetics*
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Core Binding Factor Alpha 3 Subunit / physiology*
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DNA Methylation
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Estrogen Receptor alpha / metabolism
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Female
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Gene Silencing
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Genes, Tumor Suppressor*
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Humans
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Mammary Neoplasms, Experimental / genetics
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Mammary Neoplasms, Experimental / physiopathology
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Mice
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Mice, Knockout
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Promoter Regions, Genetic
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Signal Transduction
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Tumor Suppressor Proteins / genetics*
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Tumor Suppressor Proteins / physiology*
Substances
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Core Binding Factor Alpha 3 Subunit
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Estrogen Receptor alpha
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Runx3 protein, human
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Runx3 protein, mouse
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Tumor Suppressor Proteins