Abstract
The tal-1 proto-oncogene encodes a helix-loop-helix DNA-binding protein that has been implicated in the formation of T cell acute lymphoblastic leukemia (T-ALL). Patients with T-ALL harbor structural rearrangements of tal-1 that result from either local DNA deletion or t(1;14)(p34;q11) chromosome translocation. By analyzing t(1;14)(p34;q11) chromosomes from a series of patients, we have now identified a discrete region of tal-1 wherein most of the translocation breakpoints occur. Moreover, mapping of tal-1 genomic DNA revealed that coding exons are situated on both sides of the t(1;14)(p34;q11) major breakpoint region. Hence, the translocated allele of tal-1 is truncated in a manner that reduces its amino acid coding potential.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Alleles
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Amino Acid Sequence
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Base Sequence
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Basic Helix-Loop-Helix Transcription Factors
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Chromosome Mapping
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Chromosomes, Human, Pair 1
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Chromosomes, Human, Pair 14
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DNA, Neoplasm / genetics
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DNA-Binding Proteins / genetics*
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Exons
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Humans
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Leukemia, T-Cell / genetics*
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Male
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Molecular Sequence Data
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / genetics*
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Proto-Oncogenes / genetics*
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T-Cell Acute Lymphocytic Leukemia Protein 1
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Transcription Factors*
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Translocation, Genetic / genetics*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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DNA, Neoplasm
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DNA-Binding Proteins
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MAS1 protein, human
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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T-Cell Acute Lymphocytic Leukemia Protein 1
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Transcription Factors
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TAL1 protein, human