Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder

Psychiatry Res. 2012 Jun 30;198(1):166-8. doi: 10.1016/j.psychres.2011.09.002. Epub 2012 Feb 27.

Abstract

The association between polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder (BPD) is investigated. This study was performed on 228 BPD patients and 234 control subjects. Among early-onset patients, the variant alleles of Glu32Lys and G-1002A increased BPD susceptibility. The haplotype "-1002G, 32Glu, 42Gly" versus the other haplotypes was significantly decreased among early-onset patients compared to controls (P=0.016).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Bipolar Disorder / genetics*
  • Chi-Square Distribution
  • DNA Mutational Analysis
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease*
  • Genotype
  • Glutamic Acid / genetics
  • Glutathione Transferase / genetics*
  • Humans
  • Linkage Disequilibrium
  • Logistic Models
  • Lysine / genetics
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics*
  • Young Adult

Substances

  • Glutamic Acid
  • GSTZ1 protein, human
  • Glutathione Transferase
  • Lysine