Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients

D Seelenfreund; S R Lobos; A Quesada; J M Saavedra; C Wolff; G López-Stewart; A V Araya; P Durruty

doi:10.1016/j.diabres.2012.01.029

Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients

Diabetes Res Clin Pract. 2012 May;96(2):e47-9. doi: 10.1016/j.diabres.2012.01.029. Epub 2012 Mar 15.

Authors

D Seelenfreund¹, S R Lobos, A Quesada, J M Saavedra, C Wolff, G López-Stewart, A V Araya, P Durruty

Affiliation

¹ Department of Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, V. Mackenna 20, Providencia, Santiago, Chile. dseelen@ciq.uchile.cl

PMID: 22425436
DOI: 10.1016/j.diabres.2012.01.029

Abstract

We investigated two single nucleotide polymorphisms of the NOS3 gene in type 2 diabetic patients (n=93) and healthy non-diabetic controls (n=76) and their relationship with smoking habits, body mass index, hypertension and dyslipidemia. Results showed that eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p<0.05).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Body Mass Index
Chile
Diabetes Mellitus, Type 2 / enzymology
Diabetes Mellitus, Type 2 / genetics*
Humans
Hypertension / enzymology*
Hypertension / genetics
Nitric Oxide Synthase Type III / genetics
Nitric Oxide Synthase Type III / metabolism*
Polymorphism, Single Nucleotide / genetics*
Smoking

Substances

NOS3 protein, human
Nitric Oxide Synthase Type III