Abstract
The factor V Leiden mutation, the most common inherited cause of thrombophilia, causes a mild hypercoagulable state. We describe a 29-year-old man, heterozygous for factor V Leiden, who developed extensive pulmonary emboli with concomitant bilateral deep venous thrombosis, likely provoked by prolonged immobility during a car trip. We then review the diagnosis, therapy, screening, and prognosis of venous thromboembolism related to factor V Leiden.
MeSH terms
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Adult
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Anticoagulants / therapeutic use
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Factor V / genetics*
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Genetic Testing
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Humans
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Male
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Prognosis
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Pulmonary Embolism / complications
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Pulmonary Embolism / diagnosis
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Pulmonary Embolism / drug therapy
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Thrombophilia / genetics*
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Ultrasonography
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Venous Thromboembolism / diagnosis
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Venous Thromboembolism / drug therapy
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Venous Thromboembolism / genetics*
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Venous Thrombosis / complications
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Venous Thrombosis / diagnostic imaging
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Venous Thrombosis / drug therapy
Substances
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Anticoagulants
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factor V Leiden
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Factor V