Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction

Psychiatry Res. 2012 Aug 30;199(1):74-6. doi: 10.1016/j.psychres.2012.03.048. Epub 2012 Apr 24.

Abstract

We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. One polymorphism in GRIA1 (rs1994862) was associated with arousal dysfunction, providing further evidence for the role of GRIA1 in mechanisms underlying SSRI-associated sexual side effects.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Depression / complications
  • Depression / drug therapy
  • Depression / genetics*
  • Female
  • Genotype
  • GluK2 Kainate Receptor
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Receptors, AMPA / genetics*
  • Receptors, Kainic Acid / genetics*
  • Selective Serotonin Reuptake Inhibitors / adverse effects*
  • Selective Serotonin Reuptake Inhibitors / therapeutic use
  • Sexual Dysfunctions, Psychological / chemically induced
  • Sexual Dysfunctions, Psychological / complications
  • Sexual Dysfunctions, Psychological / genetics*

Substances

  • Receptors, AMPA
  • Receptors, Kainic Acid
  • Serotonin Uptake Inhibitors
  • glutamate receptor ionotropic, AMPA 3
  • glutamate receptor ionotropic, AMPA 1