Abstract
We investigated the expression of AIF (apoptotic inducing factor) and CGRP (calcitonin gene related peptide) at autopsy material of pineal gland and thymus of people after 60 years old. The expression of AIF and CGRP was identified in both organs, but it did not change with age, which demonstrates the probable safety of functional activity of neuroimmunoendocrine system at aging. We found correlation between expression AIF and CGRP at pineal gland, but the correlation at thymus wasn't found. It is possible that pineal gland can express unidentified signal molecule controlling the expression of AIF and CGRP.
MeSH terms
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Aged
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Aged, 80 and over
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Aging* / genetics
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Aging* / metabolism
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Aging* / pathology
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Apoptosis / genetics*
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Apoptosis Inducing Factor* / genetics
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Apoptosis Inducing Factor* / metabolism
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Calcitonin Gene-Related Peptide* / genetics
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Calcitonin Gene-Related Peptide* / metabolism
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Female
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Gene Expression Regulation
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Humans
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Immunohistochemistry
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Male
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Middle Aged
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Mitochondria / metabolism
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Neuroimmunomodulation / physiology
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Pineal Gland* / metabolism
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Pineal Gland* / pathology
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Statistics as Topic
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Synaptic Transmission / physiology
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Thymus Gland* / metabolism
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Thymus Gland* / pathology
Substances
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Apoptosis Inducing Factor
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Calcitonin Gene-Related Peptide