USP2a activation of MYC in prostate cancer

Cancer Discov. 2012 Mar;2(3):206-7. doi: 10.1158/2159-8290.CD-12-0027.

Abstract

Ubiquitin-specific protease 2a, a deubiquitinating enzyme, elevates MYC levels in prostate cancer cells via its stabilization of MDM2, undermining p53 regulation of microRNAs that target MYC mRNA.

Publication types

  • Comment

MeSH terms

  • Endopeptidases / biosynthesis*
  • Humans
  • Male
  • MicroRNAs / metabolism*
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / metabolism*
  • Proto-Oncogene Proteins c-myc / biosynthesis*
  • Ubiquitin Thiolesterase

Substances

  • MYC protein, human
  • MicroRNAs
  • Proto-Oncogene Proteins c-myc
  • Endopeptidases
  • USP2 protein, human
  • Ubiquitin Thiolesterase