Abstract
Ubiquitin-specific protease 2a, a deubiquitinating enzyme, elevates MYC levels in prostate cancer cells via its stabilization of MDM2, undermining p53 regulation of microRNAs that target MYC mRNA.
©2012 AACR.
MeSH terms
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Endopeptidases / biosynthesis*
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Humans
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Male
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MicroRNAs / metabolism*
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Prostatic Neoplasms / genetics*
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Prostatic Neoplasms / metabolism*
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Proto-Oncogene Proteins c-myc / biosynthesis*
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Ubiquitin Thiolesterase
Substances
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MYC protein, human
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MicroRNAs
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Proto-Oncogene Proteins c-myc
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Endopeptidases
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USP2 protein, human
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Ubiquitin Thiolesterase