Effects of compound danshen tablets on spatial cognition and expression of brain beta-amyloid precursor protein in a rat model of Alzheimer's disease

J Tradit Chin Med. 2012 Mar;32(1):63-6. doi: 10.1016/s0254-6272(12)60033-8.

Abstract

Objective: To observe the effects of Compound Danshen Tablets (CDST) on spatial cognition and expression of brain b-amyloid precursor protein (beta-APP) in a rat model of Alzheimer's disease.

Methods: The rat model of Alzheimer's disease (AD) was established using D-galactose to cause subacute aging combined with Meynert nucleus damage. Rat behavior was monitored using the Morris water maze, and the expression of beta-APP in rat brain tissue was detected via immunohistochemistry.

Results: CDST significantly improved spatial cognition and decreased beta-APP expression in the cortex and hippocampus (P < 0.05, P < 0.01).

Conclusions: CDST can significantly improve spatial cognition in a rat model of AD. This observation is possibly related to a reduction in beta-APP expression in the rat brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / psychology
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / metabolism*
  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Cognition / drug effects*
  • Disease Models, Animal
  • Drugs, Chinese Herbal / administration & dosage*
  • Female
  • Humans
  • Male
  • Rats
  • Salvia miltiorrhiza / chemistry*

Substances

  • Amyloid beta-Protein Precursor
  • Drugs, Chinese Herbal