From genes to cognition in tuberous sclerosis: implications for mTOR inhibitor-based treatment approaches

Neuropharmacology. 2013 May:68:97-105. doi: 10.1016/j.neuropharm.2012.05.015. Epub 2012 May 22.

Abstract

Tuberous sclerosis (TSC) is a neurocutaneous disorder with an autosomal-dominant pattern of inheritance and is caused by heterozygous mutations in the TSC1 or TSC2 gene. Neuropsychiatric conditions, including intellectual disability, autism and epilepsy, are highly prevalent in TSC populations. Here, I review recent findings that shed light on some of the neurobiological mechanisms that may contribute to the pathogenesis of TSC-associated neuropsychiatric impairments. Emerging intervention studies in animal models show striking effects of mTORC1 inhibitors on TSC-related CNS manifestations. Translational studies that assess the effects of mTORC1 inhibitors on neuropsychiatric phenotypes in human TSC individuals are underway. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cognition*
  • Disease Models, Animal
  • Humans
  • Phenotype
  • Protein Kinase Inhibitors / therapeutic use*
  • TOR Serine-Threonine Kinases / antagonists & inhibitors*
  • Tuberous Sclerosis / drug therapy*
  • Tuberous Sclerosis / genetics
  • Tuberous Sclerosis / psychology

Substances

  • Protein Kinase Inhibitors
  • TOR Serine-Threonine Kinases