Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism

Tatjana Bordukalo-Niksic; Jasminka Stefulj; Ana Matosic; Gordana Mokrovic; Lipa Cicin-Sain

doi:10.1016/j.psychres.2012.04.031

Combination of polymorphic variants in serotonin transporter and monoamine oxidase-A genes may influence the risk for early-onset alcoholism

Psychiatry Res. 2012 Dec 30;200(2-3):1041-3. doi: 10.1016/j.psychres.2012.04.031. Epub 2012 May 23.

Authors

Tatjana Bordukalo-Niksic¹, Jasminka Stefulj, Ana Matosic, Gordana Mokrovic, Lipa Cicin-Sain

Affiliation

¹ Laboratory of Neurochemistry and Molecular Neurobiology, Department of Molecular Biology, Rudjer Boskovic Institute, Bijenicka 54, HR-10000 Zagreb, Croatia.

PMID: 22627167
DOI: 10.1016/j.psychres.2012.04.031

Abstract

The combinatory effect of polymorphisms in serotonin transporter and monoamine oxidase-A genes on the aetiopathogenesis of alcoholism was investigated in a sample of 714 individuals. Increased frequency of subjects having three 'suspected' genotypes (5-HTTLPR-LL, STin2-1010 and MAO-A 3-repeat allele) was found among type-2 alcoholic patients (P=0.0189). Results highlight serotonergic/genetic contribution to early-onset alcoholism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age of Onset
Alcoholism / genetics*
Alleles
Gene Frequency
Genetic Predisposition to Disease*
Genotype
Humans
Male
Monoamine Oxidase / genetics*
Polymorphism, Genetic
Serotonin Plasma Membrane Transport Proteins / genetics*

Substances

Serotonin Plasma Membrane Transport Proteins
Monoamine Oxidase