Abstract
Insulin-like growth factor-I (IGF-I) is closely related to insulin but has distinct metabolic actions. IGF-I is an important stimulant of protein synthesis in muscle, but it also stimulates free fatty acid use. The administration of IGF-I to patients with extreme insulin resistance results in improvement in glycemic control, and IGF-I is associated with lowering glucose and enhancing insulin sensitivity in Type 1 and Type 2 diabetes. However, patients with diabetes are also sensitive to stimulation of side effects in response to IGF-I. IGF-I coordinately links growth hormone and insulin actions and has direct effects on intermediary metabolism.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Blood Glucose / metabolism
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Diabetes Mellitus, Type 1 / drug therapy
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Diabetes Mellitus, Type 1 / metabolism*
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / metabolism*
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Dietary Carbohydrates / metabolism
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Dietary Fats / metabolism
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Dietary Proteins / metabolism
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Female
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Humans
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Hyperglycemia / drug therapy
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Hypoglycemic Agents / therapeutic use
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Insulin-Like Growth Factor I / genetics
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Insulin-Like Growth Factor I / metabolism*
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Insulin-Like Growth Factor I / therapeutic use
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Male
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Metabolic Syndrome / drug therapy
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Metabolic Syndrome / metabolism*
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Mice
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Polymorphism, Genetic
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Rats
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Severity of Illness Index
Substances
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Blood Glucose
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Dietary Carbohydrates
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Dietary Fats
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Dietary Proteins
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Hypoglycemic Agents
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Insulin-Like Growth Factor I