Tenascin-C (TN-C), a hexameric extracellular matrix glycoprotein, is a pleiotropic regulator of a variety of cell functions associated with embryogenesis, wound healing, cell proliferation, differentiation, motility, and nerve regeneration. Due to its role in remodeling processes, TN-C is involved with many pathologic states including cardiac and vascular diseases as well as inflammation and cancer. Assessment of circulating TN-C may help with identification of heart disease, especially in conjunction other cardiac biomarkers. It may be considered a specific biomarker useful in detecting cardiac pathology, especially in early disease stages and subsequent monitoring of cardiologic therapy. This review will highlight the biochemistry and usefulness of TN-C in clinical laboratory diagnostics to date.
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