Association of hypercholesterolemia and apolipoprotein E4 in school children

H Yanagi; Y Shimakura; Y Yamanouchi; Y Watanabe; S Tsuchiya; H Hamaguchi

doi:10.1111/j.1399-0004.1990.tb03579.x

Association of hypercholesterolemia and apolipoprotein E4 in school children

Clin Genet. 1990 Oct;38(4):264-9. doi: 10.1111/j.1399-0004.1990.tb03579.x.

Authors

H Yanagi¹, Y Shimakura, Y Yamanouchi, Y Watanabe, S Tsuchiya, H Hamaguchi

Affiliation

¹ Department of Human Genetics, University of Tsukuba, Japan.

PMID: 2268973
DOI: 10.1111/j.1399-0004.1990.tb03579.x

Abstract

To investigate the association of apolipoprotein (APO) E4 and hypercholesterolemia in children, we studied the APOE phenotypes of 51 school-age children with hypercholesterolemia and of 51 age, sex and obesity index-matched controls with normocholesterolemia by two-dimensional gel electrophoresis APOE4 was present in 21 of 51 hypercholesterolemic children (41.2%), and in nine of 51 control subjects (17.6%). The difference was significant (p less than 0.01). This finding indicates that APOE4 is associated with hypercholesterolemia in children.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Apolipoprotein E4
Apolipoproteins E / genetics*
Child
Female
Gene Frequency / genetics
Genetic Testing
Humans
Hyperlipoproteinemia Type II / genetics*
Japan
Male
Phenotype*
Polymorphism, Genetic / genetics*

Substances

Apolipoprotein E4
Apolipoproteins E