Abstract
Rab geranylgeranyl transferase is an enzyme responsible for double geranylgeranylation of Rab proteins in all eukaryotic cells. In the present article we would like to focus on new findings concerning the holoenzyme structure and mechanism of catalytic activity, its mode of regulation and consequences of RGGT deficiency in different eucaryotic model organisms and patients.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alkyl and Aryl Transferases / chemistry
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Alkyl and Aryl Transferases / genetics
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Alkyl and Aryl Transferases / metabolism*
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Amino Acid Motifs
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Animals
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Humans
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Multienzyme Complexes / genetics
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Multienzyme Complexes / metabolism*
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Protein Prenylation / physiology*
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Protein Transport / physiology
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rab GTP-Binding Proteins / genetics
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rab GTP-Binding Proteins / metabolism*
Substances
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Multienzyme Complexes
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Alkyl and Aryl Transferases
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Rab geranylgeranyltransferase
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rab GTP-Binding Proteins