Neurological disorders: towards a mechanistic understanding of restless legs syndrome

Curr Biol. 2012 Jun 19;22(12):R485-6. doi: 10.1016/j.cub.2012.05.004.

Abstract

Restless legs syndrome is a curious neurological disorder of unknown aetiology. A new study has found that Drosophila mutants in the fly homologue of a human gene, BTBD9, that has been implicated as a risk factor for restless legs display important features of the syndrome.

Publication types

  • Comment

MeSH terms

  • Animals
  • Brain / metabolism*
  • Carrier Proteins / genetics*
  • Dopamine / metabolism*
  • Drosophila Proteins / genetics*
  • Humans
  • Iron / metabolism*
  • Restless Legs Syndrome / genetics*
  • Restless Legs Syndrome / physiopathology*
  • Sleep Deprivation / genetics*

Substances

  • BTBD9 protein, Drosophila
  • Carrier Proteins
  • Drosophila Proteins
  • Iron
  • Dopamine