Abstract
This article focuses on the emerging roles for phosphatidylinositol 4-phosphate and the phosphatidylinositol 4-kinases in cancer. Phosphatidylinositol 4-phosphate is a common substrate for both the phosphatidylinositol 3-kinase and phospholipase C pathways, and has been implicated in the membrane targeting of proteins such as Girdin/GIV and OSBP. Alterations to phosphatidylinositol 4-kinase expression levels can modulate MAP kinase and Akt signalling, and are important for chemoresistance, tumour angiogenesis and the suppression of apoptosis and metastases. Recent improvements in high-throughput screening assays, and the discoveries that some anti-viral molecules are isoform selective phosphatidylinositol 4-kinase inhibitors have advanced the drugability of these enzymes.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
MeSH terms
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1-Phosphatidylinositol 4-Kinase / physiology*
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Antineoplastic Agents / pharmacology
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Apoptosis
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Drug Resistance, Neoplasm
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High-Throughput Screening Assays
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Humans
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Membrane Lipids / metabolism
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Microfilament Proteins / physiology
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Molecular Targeted Therapy
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Neoplasm Metastasis
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Neoplasm Proteins / physiology*
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Neoplasms / drug therapy
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Neoplasms / metabolism*
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Neovascularization, Pathologic / metabolism
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Phosphatidylinositol 3-Kinases / physiology
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Phosphatidylinositol Phosphates / physiology*
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Phospholipids / metabolism
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Signal Transduction / physiology*
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Type C Phospholipases / physiology
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Vesicular Transport Proteins / physiology
Substances
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Antineoplastic Agents
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CCDC88A protein, human
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Membrane Lipids
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Microfilament Proteins
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Neoplasm Proteins
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Phosphatidylinositol Phosphates
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Phospholipids
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Vesicular Transport Proteins
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phosphatidylinositol 4-phosphate
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Phosphatidylinositol 3-Kinases
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1-Phosphatidylinositol 4-Kinase
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Type C Phospholipases