Endocrine metabolic disorders in patients with breast cancer, carriers of BRCA1 gene mutations
Bull Exp Biol Med. 2012 Mar;152(5):610-2.
doi: 10.1007/s10517-012-1588-9.
[Article in
English,
Russian]
Affiliation
- 1 N. N. Petrov Institute of Oncology, Ministry of Health and Social Development of the Russian Federation, St. Petersburg, Russia. levmb@endocrin.spb.ru
Abstract
Two groups of breast cancer patients (53±2 years) in clinical remission receiving no specific therapy were examined: group 1, with BRCA1 gene mutations (N=11) and group 2, without mutations of this kind (N=11). The two groups did not differ by insulinemia and glycemia, insulin resistance index, blood levels of thyrotropic hormone, sex hormone-binding globulin, insulin-like growth factor-1, triglycerides, or lipoproteins. In group 1, blood estradiol level was higher. Intensive glucose-induced generation of reactive oxygen species in these patients was associated with a decrease of cholesterolemia, of the C-peptide/insulin proportion, and a trend to higher urinary excretion of 4-hydroxyestrone, one of the most genotoxic catecholestrogens. BRCA1 gene mutations in breast cancer patients were associated with signs of estrogenization and a pro-genotoxic shift in the estrogen and glucose system, which could modulate the disease course and requires correction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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BRCA1 Protein / genetics
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BRCA1 Protein / metabolism*
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Blood Glucose / analysis
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism*
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Breast Neoplasms / pathology
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C-Peptide / blood
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Endocrine System / metabolism*
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Endocrine System / pathology
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Estradiol / blood*
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Female
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Humans
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Hydroxyestrones / urine
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Insulin / blood
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Insulin Resistance
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Insulin-Like Growth Factor I / metabolism
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Lipoproteins / blood
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Middle Aged
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Mutation
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Reactive Oxygen Species / blood
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Sex Hormone-Binding Globulin / metabolism
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Thyrotropin / blood
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Triglycerides / blood
Substances
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BRCA1 Protein
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BRCA1 protein, human
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Blood Glucose
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C-Peptide
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Hydroxyestrones
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Insulin
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Lipoproteins
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Reactive Oxygen Species
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Sex Hormone-Binding Globulin
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Triglycerides
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4-hydroxyestrone
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Estradiol
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Insulin-Like Growth Factor I
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Thyrotropin