Abstract
We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alleles
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Angiotensin-Converting Enzyme Inhibitors / pharmacology*
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Animals
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Anterior Temporal Lobectomy
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Anticonvulsants / pharmacology*
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Carbamazepine / pharmacology*
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Epilepsy, Temporal Lobe / genetics
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Epilepsy, Temporal Lobe / pathology
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Epilepsy, Temporal Lobe / physiopathology*
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Epilepsy, Temporal Lobe / surgery
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Genotype
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Humans
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INDEL Mutation
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Male
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Mice
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Mice, Inbred C57BL
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Peptidyl-Dipeptidase A / genetics
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Peptidyl-Dipeptidase A / physiology*
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Polymorphism, Genetic / genetics
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Temporal Lobe / drug effects
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Temporal Lobe / pathology
Substances
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Angiotensin-Converting Enzyme Inhibitors
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Anticonvulsants
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Carbamazepine
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Peptidyl-Dipeptidase A