Comparative study on experimental autoimmune pancreatitis and its extrapancreatic involvement in mice

Pancreas. 2012 Nov;41(8):1255-62. doi: 10.1097/MPA.0b013e31824a0e58.

Abstract

Objective: The objective of the study was to study the relationship between autoimmune pancreatitis (AIP) and colitis in C57BL/6 interleukin 10-deficient (IL-10KO) mice and to compare the extrapancreatic involvement of AIP between IL-10KO and MRL/Mp mice that developed pancreatitis.

Methods: Six-week-old female IL-10KO and MRL/Mp mice were injected intraperitoneally with polyinosinic polycytidylic acid (poly I:C) twice weekly for 8 or 12 weeks, respectively. The mice were killed, and the severity of inflammation in the pancreas, colon, liver, bile duct, and salivary gland was assessed using histological scoring systems. T-cell subsets derived from IL-10KO mice with pancreatitis were adoptively transferred into recombination activating gene 2-deficient mice.

Results: Administration of poly I:C induced pancreatitis and accelerated the development of colitis in IL-10KO mice. Pancreatitis was characterized by specific destruction of exocrine glands and the production of various autoantibodies. Involvement of the liver and bile duct was observed in both IL-10KO and MRL/Mp mice, but sialadenitis was present only in MRL/Mp mice. Adoptive transfer of CD4(+) T cells from AIP mice induced pancreatitis in recipient mice.

Conclusions: Pancreatitis in IL-10KO mice resembles human type 1 AIP and is not associated with colitis. Genetic background may affect susceptibility to extrapancreatic involvement in type 1 AIP.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adoptive Transfer / adverse effects
  • Animals
  • Autoantibodies / blood
  • Autoantibodies / immunology
  • Autoimmune Diseases / genetics
  • Autoimmune Diseases / immunology*
  • Autoimmune Diseases / pathology
  • CD4-Positive T-Lymphocytes / drug effects
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / transplantation
  • Carboxymethylcellulose Sodium / administration & dosage
  • Carboxymethylcellulose Sodium / analogs & derivatives
  • Cholangitis / chemically induced
  • Cholangitis / genetics
  • Cholangitis / immunology
  • Cholangitis / pathology
  • Colitis / chemically induced
  • Colitis / genetics
  • Colitis / immunology
  • Colitis / pathology
  • Disease Models, Animal
  • Exocrine Glands / drug effects
  • Exocrine Glands / immunology
  • Exocrine Glands / pathology
  • Female
  • Hepatitis / genetics
  • Hepatitis / immunology
  • Hepatitis / pathology
  • Humans
  • Interferon Inducers / administration & dosage
  • Interleukin-10 / genetics
  • Interleukin-10 / immunology
  • Mice
  • Mice, Inbred MRL lpr
  • Mice, Knockout
  • Pancreatitis / chemically induced
  • Pancreatitis / genetics
  • Pancreatitis / immunology*
  • Pancreatitis / pathology
  • Poly I-C / administration & dosage
  • Polylysine / administration & dosage
  • Polylysine / analogs & derivatives
  • Severity of Illness Index
  • Sialadenitis / chemically induced
  • Sialadenitis / genetics
  • Sialadenitis / immunology
  • Sialadenitis / pathology

Substances

  • Autoantibodies
  • IL10 protein, mouse
  • Interferon Inducers
  • Interleukin-10
  • Polylysine
  • poly ICLC
  • Carboxymethylcellulose Sodium
  • Poly I-C