Bradykinin β2 receptor -58T/C gene polymorphism and essential hypertension: a meta-analysis

PLoS One. 2012;7(8):e43068. doi: 10.1371/journal.pone.0043068. Epub 2012 Aug 10.

Abstract

Background: Research has shown that bradykinin β(2) receptor (BDKRB2) -58T/C gene polymorphism is correlated with the risk of essential hypertension (EH), but the results remain inconclusive.

Objective and methods: The objective of this study was to explore the association between BDKRB2-58T/C gene polymorphism and EH. A meta-analysis of 11 studies with 3882 subjects was conducted. Pooled odds ratios (ORs) for the association between BDKRB2-58T/C gene polymorphism and EH and their corresponding 95% confidence intervals (CIs) were estimated using the random effects model.

Results: The BDKRB2-58T/C gene polymorphism was significantly correlated with EH under an allelic genetic model (OR = 1.24, 95% CI = 1.05-1.46; P = 0.01), a dominant genetic model (OR = 0.65, 95% CI = 0.47-0.90; P = 0.01), a recessive genetic model (OR = 1.146, 95% CI = 1.035-1.269; P = 0.009), a homozygote genetic model (OR = 1.134, 95% CI = 1.048-1.228; P = 0.002), and a heterozygote genetic model (OR = 1.060, 95% CI = 1.009-1.112; P = 0.019).

Conclusions: The BDKRB2-58T/C gene polymorphism is associated with increased EH risk. The results of this study suggest that carriers of the -58C allele are susceptible to EH.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Gene Frequency
  • Genes, Dominant
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Hypertension / genetics*
  • Polymorphism, Single Nucleotide*
  • Publication Bias
  • Receptor, Bradykinin B2 / genetics*

Substances

  • Receptor, Bradykinin B2

Grants and funding

This work was funded by the National Natural Science Foundation of China (NSFC 81100073 to Dr Yan-yan Li) and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.