Gene-gene interactions in IL23/Th17 pathway contribute to psoriasis susceptibility in Chinese Han population

J Eur Acad Dermatol Venereol. 2013 Sep;27(9):1156-62. doi: 10.1111/j.1468-3083.2012.04683.x. Epub 2012 Aug 22.

Abstract

Background: Psoriasis is a common chronic inflammatory skin disease. IL23/Th17 is a newly confirmed pathway in psoriasis.

Objective: To investigate the gene-gene interactions in IL23/Th17 pathway underlying psoriasis.

Methods: A total of 299 single-nucleotide polymorphisms from 11 genes in IL23/Th17 pathway were genotyped on 1139 patients with psoriasis and 1694 controls. Multifactor dimensionality reduction and logistic regression algorithms were applied to explore the gene-gene interactions.

Results: We found that there were a three-way interaction among IL21, CCR4 and TNF(χ(2) = 5.02(1), P = 0.025) and three pair-wise gene-gene interactions between IL12RB1 and CCR4(χ(2) = 11.66(4), P = 0.0201), IL22 and CCR4 (χ(2) = 11.97(4), P = 0.0176), IL12RB1 and IL6 (χ(2) = 7.31(1), P = 0.0069) in psoriasis.

Conclusions: Our results might be helpful for explaining the missing heritability of the psoriasis due to epistasis and provide a deep insight into the important role of the IL23/Th17 pathway in the pathogenesis of psoriasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People / genetics
  • Case-Control Studies
  • Epistasis, Genetic
  • Female
  • Genetic Predisposition to Disease*
  • Humans
  • Male
  • Psoriasis / genetics*
  • Receptors, Interleukin / genetics*
  • Receptors, Interleukin-17 / genetics*
  • Signal Transduction / genetics

Substances

  • IL17RA protein, human
  • IL23R protein, human
  • Receptors, Interleukin
  • Receptors, Interleukin-17