Abstract
Interferon-gamma (IFN-γ) is crucial for immunity against different pathogens due to its broad effects on the multiple arms of the immune system. The regulation of IFN-γ immunity is of extensive interest to research as well as practical activity for drug discovery. New evidence supports previous findings that ubiquitin-like protein ISG15 acts as an extracellular cytokine and promotes IFN-γ production, providing intriguing insights of the importance of ISG15 into the control of human mycobacterial disease.
MeSH terms
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Adolescent
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Amino Acid Sequence
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Animals
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BCG Vaccine / immunology
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CD3 Complex / metabolism
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Child
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Cytokines / genetics
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Cytokines / metabolism*
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Female
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Humans
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Interferon-gamma / metabolism*
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Killer Cells, Natural / immunology
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Killer Cells, Natural / metabolism
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Lymphocytes / immunology
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Lymphocytes / metabolism
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Male
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Mice
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Mycobacterium Infections / immunology
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Mycobacterium Infections / metabolism*
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Mycobacterium Infections / prevention & control
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Ubiquitins / genetics
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Ubiquitins / metabolism*
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Vaccination
Substances
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BCG Vaccine
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CD3 Complex
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Cytokines
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Ubiquitins
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ISG15 protein, human
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Interferon-gamma