Janus-faced PIDD: a sensor for DNA damage-induced cell death or survival?

Francis McCoy; Laura Eckard; Leta K Nutt

doi:10.1016/j.molcel.2012.08.019

Janus-faced PIDD: a sensor for DNA damage-induced cell death or survival?

Mol Cell. 2012 Sep 14;47(5):667-8. doi: 10.1016/j.molcel.2012.08.019.

Authors

Francis McCoy¹, Laura Eckard, Leta K Nutt

Affiliation

¹ Department of Biochemistry, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

PMID: 22980457
DOI: 10.1016/j.molcel.2012.08.019

Abstract

In this issue of Molecular Cell, an activator of the PIDDosome (a complex comprising of PIDD, RAIDD, and caspase-2) is described in experiments detailing endogenous PIDDosome assembly and caspase-2 function after DNA damage in the presence of Chk1 suppression (Ando et al., 2012).

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