Abstract
Few descriptions of miliary brain metastases have been reported. We report the case of an adenocarcinoma of the lung associated with metachronous miliary brain and lung metastases with an echinoderm microtubule-associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) gene translocation. The patient was treated with crizotinib and showed a twelve-month progression-free survival. Clinicians should be attentive of the evolution of brain metastases with patients presenting EML4-ALK translocation.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
MeSH terms
-
Adenocarcinoma / diagnosis*
-
Adenocarcinoma / drug therapy
-
Adenocarcinoma / genetics
-
Adenocarcinoma / secondary
-
Adult
-
Antibodies, Monoclonal, Humanized / administration & dosage
-
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
-
Bevacizumab
-
Brain Neoplasms / diagnosis*
-
Brain Neoplasms / drug therapy
-
Brain Neoplasms / genetics
-
Brain Neoplasms / secondary
-
Cisplatin / administration & dosage
-
Crizotinib
-
DNA Mutational Analysis
-
Deoxycytidine / administration & dosage
-
Deoxycytidine / analogs & derivatives
-
Fatal Outcome
-
Female
-
Gemcitabine
-
Humans
-
Lung Neoplasms / diagnosis*
-
Lung Neoplasms / drug therapy
-
Lung Neoplasms / genetics
-
Lung Neoplasms / pathology
-
Molecular Diagnostic Techniques
-
Oncogene Proteins, Fusion / metabolism*
-
Pyrazoles / administration & dosage
-
Pyridines / administration & dosage
-
Translocation, Genetic
Substances
-
Antibodies, Monoclonal, Humanized
-
EML4-ALK fusion protein, human
-
Oncogene Proteins, Fusion
-
Pyrazoles
-
Pyridines
-
Deoxycytidine
-
Bevacizumab
-
Crizotinib
-
Cisplatin
-
Gemcitabine