Abstract
About a quarter of children with Down syndrome and transient abnormal myelopoiesis (TAM) progress to acute megakaryoblastic leukemia (AMKL). We describe isolated dysmegakaryopoiesis despite complete resolution of TAM in an 18-month-old girl, who developed AMKL 6 months later.
MeSH terms
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Cell Lineage
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Cell Nucleus / ultrastructure
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Clone Cells
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Disease Progression
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Down Syndrome / blood*
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Down Syndrome / complications*
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Down Syndrome / etiology
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Down Syndrome / genetics
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Female
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GATA1 Transcription Factor / genetics*
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Humans
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Infant, Newborn
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Leukemia, Megakaryoblastic, Acute / etiology*
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Leukemia, Megakaryoblastic, Acute / genetics
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Leukemia, Megakaryoblastic, Acute / pathology
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Leukemoid Reaction / etiology*
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Leukemoid Reaction / genetics
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Megakaryocytes / pathology
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Preleukemia / etiology*
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Preleukemia / pathology
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Thrombocytopenia / etiology*
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Thrombopoiesis*
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Vacuoles / ultrastructure
Substances
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GATA1 Transcription Factor
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GATA1 protein, human
Supplementary concepts
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Myeloproliferative Syndrome, Transient