Prominent megakaryocytic dysplasia after regression of transient abnormal myelopoiesis associated with GATA-1 mutation

J Pediatr Hematol Oncol. 2012 Nov;34(8):640. doi: 10.1097/MPH.0b013e31826e7dba.

Abstract

About a quarter of children with Down syndrome and transient abnormal myelopoiesis (TAM) progress to acute megakaryoblastic leukemia (AMKL). We describe isolated dysmegakaryopoiesis despite complete resolution of TAM in an 18-month-old girl, who developed AMKL 6 months later.

Publication types

  • Case Reports

MeSH terms

  • Cell Lineage
  • Cell Nucleus / ultrastructure
  • Clone Cells
  • Disease Progression
  • Down Syndrome / blood*
  • Down Syndrome / complications*
  • Down Syndrome / etiology
  • Down Syndrome / genetics
  • Female
  • GATA1 Transcription Factor / genetics*
  • Humans
  • Infant, Newborn
  • Leukemia, Megakaryoblastic, Acute / etiology*
  • Leukemia, Megakaryoblastic, Acute / genetics
  • Leukemia, Megakaryoblastic, Acute / pathology
  • Leukemoid Reaction / etiology*
  • Leukemoid Reaction / genetics
  • Megakaryocytes / pathology
  • Preleukemia / etiology*
  • Preleukemia / pathology
  • Thrombocytopenia / etiology*
  • Thrombopoiesis*
  • Vacuoles / ultrastructure

Substances

  • GATA1 Transcription Factor
  • GATA1 protein, human

Supplementary concepts

  • Myeloproliferative Syndrome, Transient