Hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma in an infant: a rare case and review of the literature

J Pediatr Hematol Oncol. 2012 Nov;34(8):635-7. doi: 10.1097/MPH.0b013e3182678e1e.

Abstract

Spontaneous rupture of adrenal neuroblastoma is very rare in infants, in contrast to neonates. This report describes a 9-month-old boy presenting with acute hemorrhagic shock due to spontaneous rupture of adrenal neuroblastoma. MYCN oncogene amplification may be a predisposing factor for spontaneous rupture and bleeding of neuroblastoma. An appropriate surgical treatment for this condition must be discussed according to the patient's general state and the tumor features, such as staging, the origin, and local invasiveness.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adrenal Gland Neoplasms / blood
  • Adrenal Gland Neoplasms / complications*
  • Adrenal Gland Neoplasms / drug therapy
  • Adrenal Gland Neoplasms / genetics
  • Adrenal Gland Neoplasms / surgery
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Cisplatin / administration & dosage
  • Crystalloid Solutions
  • Cyclophosphamide / administration & dosage
  • Doxorubicin / administration & dosage
  • Erythrocyte Transfusion
  • Genes, myc
  • Hematopoietic Stem Cell Transplantation
  • Hemoperitoneum / etiology
  • Humans
  • Infant
  • Isotonic Solutions / therapeutic use
  • Male
  • Melphalan / administration & dosage
  • Neuroblastoma / blood
  • Neuroblastoma / complications*
  • Neuroblastoma / drug therapy
  • Neuroblastoma / genetics
  • Neuroblastoma / surgery
  • Remission Induction
  • Risk Factors
  • Rupture, Spontaneous
  • Shock, Hemorrhagic / etiology*
  • Shock, Hemorrhagic / therapy
  • Thiotepa / administration & dosage
  • Transplantation, Autologous
  • Vincristine / administration & dosage

Substances

  • Crystalloid Solutions
  • Isotonic Solutions
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Thiotepa
  • Cisplatin
  • Melphalan