p53 codon 72 polymorphism and hematological cancer risk: an update meta-analysis

PLoS One. 2012;7(9):e45820. doi: 10.1371/journal.pone.0045820. Epub 2012 Sep 24.

Abstract

Background: Previous studies on the association of p53 codon 72 (Arg72Pro) polymorphism with hematological malignancies risk have produced conflicting results. The purpose of this meta-analysis is to define the effect of p53 Arg72Pro polymorphism on hematological malignancies risk.

Methodology/principal findings: Through searching PubMed databases (or hand searching) up to April 2012 using the following MeSH terms and keywords: "p53", "codon 72" "polymorphism" and "leukemia", or "lymphoma", or "myeloma", thirteen were identified as eligible articles in this meta-analysis for p53 Arg72Pro polymorphism (2,731 cases and 7, 356 controls), including nine studies on leukemia (1,266 cases and 4, 474 controls), three studies on lymphoma (1,359 cases and 2,652 controls), and one study on myeloma. The overall results suggested that p53 Arg72Pro polymorphism was not associated with hematological malignancies risk. In stratified analyses, significantly increased non-Hodgkin lymphomas risk was found in p53 Arg72Pro polymorphism heterozygote model (Arg/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.02-1.35) and dominant model (Arg/Pro+Pro/Pro vs. Arg/Arg: OR = 1.18, 95%CI: 1.03-1.34), but no significant association was found between leukemia risk and p53 Arg72Pro polymorphism. Further studies showed no association between leukemia risk and p53 Arg72Pro polymorphism when stratified in subtypes of leukemias, ethnicities and sources of controls.

Conclusions/significance: This meta-analysis indicates that the p53 Arg72Pro polymorphism may contribute to susceptibility to non-Hodgkin lymphomas.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Case-Control Studies
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Lymphoma, Non-Hodgkin / genetics*
  • Polymorphism, Single Nucleotide*
  • Publication Bias
  • Risk
  • Sequence Analysis, DNA
  • Tumor Suppressor Protein p53 / genetics*

Substances

  • TP53 protein, human
  • Tumor Suppressor Protein p53

Grants and funding

This study was supported by the grants from Zhejiang Provincial Natural Science Foundation of China (Y12H160154), Health Bureau of Zhejiang Province (2011KYB012), Zhejiang Provincial Administration of Traditional Chinese Medicine (2011ZA010) and the Fundamental Research Funds for the Central Universities (2011QNA7018, 2012QNA7019). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.