De novo Ph negative T-cell lymphoblastic leukaemia associated with bcr gene rearrangement

P G Middleton; E V Davison; M M Reid; S J Proctor

doi:10.1016/0145-2126(90)90152-y

De novo Ph negative T-cell lymphoblastic leukaemia associated with bcr gene rearrangement

Leuk Res. 1990;14(1):99-103. doi: 10.1016/0145-2126(90)90152-y.

Authors

P G Middleton¹, E V Davison, M M Reid, S J Proctor

Affiliation

¹ Department of Haematology, University of Newcastle upon Tyne, England.

PMID: 2304357
DOI: 10.1016/0145-2126(90)90152-y

Abstract

One case of de novo Ph-negative T-cell acute lymphoblastic leukaemia has been found to have a classical breakpoint cluster region (bcr) rearrangement of the type seen in chronic granulocytic leukaemia. There were no haematological features to suggest a previous chronic phase. This case represents the first report of this rearrangement in Ph negative acute T-lymphoblastic leukaemia at presentation. The implications for various therapeutic options in such patients are discussed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Blotting, Southern
Chromosomes, Human, Pair 22
Gene Rearrangement*
Humans
Leukemia-Lymphoma, Adult T-Cell / genetics*
Male
Multigene Family*
Oncogenes*
Philadelphia Chromosome*