Abstract
The influence of drugs improving sympathoadrenal system status on natural killer (NK) functional activity was studied in lung cancer patients. The activity of adenosine-metabolizing enzymes (adenosine deaminase and 5'-nucleotidase) in NK cells was found significantly altered, suggesting the involvement of this phenomenon in decreasing NK activity under tumor growth. Pharmacological correction of sympathoadrenal system status was followed by an increase in NK functional activity in lung cancer patients.
Publication types
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Comparative Study
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English Abstract
MeSH terms
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5'-Nucleotidase / metabolism
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Adenosine Deaminase / metabolism
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Adrenal Glands / drug effects*
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Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Humans
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Killer Cells, Natural / enzymology
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Killer Cells, Natural / immunology*
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Lung Neoplasms / drug therapy
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Lung Neoplasms / immunology*
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Middle Aged
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Oxprenolol / pharmacology*
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Stimulation, Chemical
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Sympathetic Nervous System / drug effects*
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Vitamin U / pharmacology*
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Vitamins / pharmacology*
Substances
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Vitamins
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Vitamin U
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Oxprenolol
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5'-Nucleotidase
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Adenosine Deaminase