No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder

Anna Leszczyńska-Rodziewicz; Aleksandra Szczepankiewicz; Monika Dmitrzak-Węglarz; Aleksandra Rajewska-Rager; Maria Skibińska; Joanna Hauser

doi:10.1016/j.psychres.2012.09.025

No association between polymorphisms and haplotypes of the AVPR1b, CRHR1 and NR3C1 genes and depression with melancholic features in the course of bipolar disorder

Psychiatry Res. 2013 May 15;207(1-2):140-2. doi: 10.1016/j.psychres.2012.09.025. Epub 2012 Oct 12.

Authors

Anna Leszczyńska-Rodziewicz¹, Aleksandra Szczepankiewicz, Monika Dmitrzak-Węglarz, Aleksandra Rajewska-Rager, Maria Skibińska, Joanna Hauser

Affiliation

¹ Department of Adult Psychiatry, Poznan University of Medical Sciences, ul. Szpitalna 27/33; 60-572 Poznan, Poland. alrodziewicz@ump.edu.pl

PMID: 23068076
DOI: 10.1016/j.psychres.2012.09.025

Abstract

The present study included 130 patients with melancholic depression in the course of bipolar disorder and 732 healthy controls. No association was found for alleles, genotypes, or haplotype analysis for NR3C1, AVPR1b, and CRHR1 genes and melancholic depression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Bipolar Disorder / genetics*
Child
Child, Preschool
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Infant
Middle Aged
Polymorphism, Genetic / genetics*
Receptors, Corticotropin-Releasing Hormone / genetics*
Receptors, Glucocorticoid / genetics*
Receptors, Vasopressin / genetics*
Young Adult

Substances

NR3C1 protein, human
Receptors, Corticotropin-Releasing Hormone
Receptors, Glucocorticoid
Receptors, Vasopressin
CRF receptor type 1