Analysis of EIF4G1 in Parkinson's disease among Asians

Neurobiol Aging. 2013 Apr;34(4):1311.e5-6. doi: 10.1016/j.neurobiolaging.2012.09.003. Epub 2012 Oct 23.

Abstract

Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Asian People / statistics & numerical data*
  • Eukaryotic Initiation Factor-4G / genetics*
  • Exons / genetics
  • Female
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / ethnology*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / ethnology*
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide / genetics
  • Prevalence
  • Risk Factors
  • United Kingdom / epidemiology

Substances

  • EIF4G1 protein, human
  • Eukaryotic Initiation Factor-4G
  • Genetic Markers