Abstract
Sequence analysis of all the exons of EIF4G1 in 96 Asian patients with Parkinson's disease (PD) did not reveal any pathogenic mutations. A novel coding variant (Pro693Ser) in exon 15 (position 2077) was detected in one PD patient but not in 539 control subjects. Analysis of a coding polymorphic variant (rs2178403) in 1330 subjects revealed similar frequency between control subjects (0.638) and PD patients (0.640). EIF4G1 is an uncommon cause of PD in our Asian cohort.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Asian People / statistics & numerical data*
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Eukaryotic Initiation Factor-4G / genetics*
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Exons / genetics
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Female
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Genetic Markers / genetics
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Genetic Predisposition to Disease / ethnology*
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Genetic Predisposition to Disease / genetics*
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Humans
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Male
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Middle Aged
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Parkinson Disease / ethnology*
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Parkinson Disease / genetics*
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Polymorphism, Single Nucleotide / genetics
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Prevalence
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Risk Factors
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United Kingdom / epidemiology
Substances
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EIF4G1 protein, human
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Eukaryotic Initiation Factor-4G
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Genetic Markers