Screening of VCP mutations in Chinese amyotrophic lateral sclerosis patients

Zhang-Yu Zou; Ming-Sheng Liu; Xiao-Guang Li; Li-Ying Cui

doi:10.1016/j.neurobiolaging.2012.10.002

Screening of VCP mutations in Chinese amyotrophic lateral sclerosis patients

Neurobiol Aging. 2013 May;34(5):1519.e3-4. doi: 10.1016/j.neurobiolaging.2012.10.002. Epub 2012 Oct 24.

Authors

Zhang-Yu Zou¹, Ming-Sheng Liu, Xiao-Guang Li, Li-Ying Cui

Affiliation

¹ Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

PMID: 23102936
DOI: 10.1016/j.neurobiolaging.2012.10.002

Abstract

Mutations in valosin-containing protein (VCP) gene have been recently found in familial and sporadic amyotrophic lateral sclerosis (ALS). To define the frequency of VCP mutations in ALS patients in Chinese population, we sequenced all 17 exons of the VCP gene in a cohort of both familial and sporadic ALS patients of Chinese origin. No nonsynonymous coding variants were identified. This indicates that VCP mutations are not a common cause of familial or sporadic ALS in Chinese population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphatases / genetics*
Amyotrophic Lateral Sclerosis / epidemiology*
Amyotrophic Lateral Sclerosis / genetics*
Cell Cycle Proteins / genetics*
China / epidemiology
Female
Genetic Markers / genetics*
Genetic Predisposition to Disease / epidemiology*
Genetic Predisposition to Disease / genetics*
Genetic Testing / statistics & numerical data
Humans
Male
Middle Aged
Mutation / genetics
Polymorphism, Single Nucleotide / genetics*
Prevalence
Risk Factors
Valosin Containing Protein

Substances

Cell Cycle Proteins
Genetic Markers
Adenosine Triphosphatases
VCP protein, human
Valosin Containing Protein