Abstract
Lack of eradication of disseminated breast cancer by chemotherapy is a central clinical problem. Even tumors that show substantial shrinkage after drug treatment frequently relapse and eventually become refractory to all drugs available. The mechanisms underlying this lack of eradication are largely undefined and it is therefore difficult to develop curative strategies using systemic anti-cancer therapy. In a recent article low DUSP4 expression was reported to activate RAS-ERK signaling in residual breast cancer after neoadjuvant chemotherapy. This may be a druggable characteristic because MEK inhibition increases docetaxel sensitivity in a xenograft model.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / pharmacology
-
Benzimidazoles / pharmacology
-
Breast Neoplasms / drug therapy*
-
Breast Neoplasms / pathology
-
Cell Proliferation
-
Docetaxel
-
Drug Resistance, Neoplasm
-
Drug Synergism
-
Dual-Specificity Phosphatases / biosynthesis*
-
Dual-Specificity Phosphatases / genetics
-
Extracellular Signal-Regulated MAP Kinases / biosynthesis
-
Extracellular Signal-Regulated MAP Kinases / genetics
-
Female
-
Humans
-
MAP Kinase Signaling System / drug effects
-
Mitogen-Activated Protein Kinase Phosphatases / biosynthesis*
-
Mitogen-Activated Protein Kinase Phosphatases / genetics
-
Mitogen-Activated Protein Kinases / antagonists & inhibitors*
-
Neoplasm Recurrence, Local / drug therapy
-
Neoplasm Recurrence, Local / prevention & control*
-
Neoplasm, Residual / drug therapy*
-
Protein Kinase Inhibitors / therapeutic use
-
Proto-Oncogene Proteins p21(ras) / biosynthesis
-
Proto-Oncogene Proteins p21(ras) / genetics
-
RNA Interference
-
Taxoids / pharmacology
Substances
-
AZD 6244
-
Antineoplastic Agents
-
Benzimidazoles
-
Protein Kinase Inhibitors
-
Taxoids
-
Docetaxel
-
Extracellular Signal-Regulated MAP Kinases
-
Mitogen-Activated Protein Kinases
-
Mitogen-Activated Protein Kinase Phosphatases
-
DUSP4 protein, human
-
Dual-Specificity Phosphatases
-
Proto-Oncogene Proteins p21(ras)