Abstract
This study was aimed to investigate the potential role of microRNA-29c (miR-29c) in regulating the sensitivities of nasopharyngeal carcinoma (NPC) to ionizing radiation (IR) and cisplatin. Low expression of miR-29c was positively associated with therapeutic resistance in 159 NPC cases. Our further in vitro and in vivo studies illustrated ectopic restoration of miR-29c substantially enhanced the sensitivity of NPC cells to IR and cisplatin treatment by promoting apoptosis. Furthermore, we detected miR-29c repressed expression of anti-apoptotic factors, Mcl-1 and Bcl-2 in NPC tissues and cell lines. These data indicate miR-29c might serve as a potential therapeutic sensitizer in NPC treatment.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects
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Apoptosis / genetics
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Apoptosis / radiation effects
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Carcinoma
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Cisplatin / pharmacology*
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Gene Expression Regulation, Neoplastic / drug effects
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Gene Expression Regulation, Neoplastic / radiation effects
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Humans
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Male
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Mice
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MicroRNAs / genetics*
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Myeloid Cell Leukemia Sequence 1 Protein
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Nasopharyngeal Carcinoma
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Nasopharyngeal Neoplasms / drug therapy*
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Nasopharyngeal Neoplasms / genetics
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Nasopharyngeal Neoplasms / radiotherapy*
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Radiation, Ionizing
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Treatment Outcome
Substances
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Antineoplastic Agents
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MIRN29a microRNA, human
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Mcl1 protein, mouse
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MicroRNAs
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Myeloid Cell Leukemia Sequence 1 Protein
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Proto-Oncogene Proteins c-bcl-2
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Cisplatin