A new ATP7B gene mutation with severe condition in two unrelated Iranian families with Wilson disease

Gene. 2013 Feb 1;514(1):48-53. doi: 10.1016/j.gene.2012.10.085. Epub 2012 Nov 13.

Abstract

Wilson disease is associated with a defect in copper metabolism and caused by different mutations in ATP7B gene. The aim of this study was to determine mutation frequency of ATP7B exons 8 and 14 in Wilson disease patients from the south of Iran. The exons 8 and 14 of ATP7B gene were analyzed in 65 unrelated Wilson disease patients by Denaturing High Performance Liquid Chromatography, and samples with abnormal peak profile were selected for direct DNA sequencing. Seven out of 65 (10.8%) patients had mutations at exon 14, including c.3061-1G>A in four and c.3207C>A in three patients. In addition, four different mutations were identified at exon 8 of six patients (9.2%). Three of these mutations have been previously reported, including c.2304delC in two patients, c.2293G>A and 2304dupC each in one patient. Furthermore, a novel mutation, c.2335T>G (p.Trp779Gly), was identified in two unrelated patients. The patients with this novel mutation demonstrated severe neuropsychiatric condition. All together, 13 out of 65 (20%) patients had mutations within exons 8 and 14. We also identified a lower frequency of the most common mutations of exons 8 and 14 in the southern Iranian population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases / genetics*
  • Adolescent
  • Adult
  • Amino Acid Sequence
  • Amino Acid Substitution
  • Cation Transport Proteins / genetics*
  • Child, Preschool
  • Copper-Transporting ATPases
  • DNA Mutational Analysis
  • Exons
  • Female
  • Frameshift Mutation
  • Hepatolenticular Degeneration / enzymology
  • Hepatolenticular Degeneration / genetics*
  • Humans
  • Iran
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Mutant Proteins / genetics
  • Mutation, Missense*
  • Pedigree
  • Phenotype
  • Sequence Deletion
  • Sequence Homology, Amino Acid
  • Spiro Compounds
  • Young Adult

Substances

  • BAS 100
  • Cation Transport Proteins
  • Mutant Proteins
  • Spiro Compounds
  • Adenosine Triphosphatases
  • ATP7B protein, human
  • Copper-Transporting ATPases