The cyclic AMP pathway

Cold Spring Harb Perspect Biol. 2012 Dec 1;4(12):a011148. doi: 10.1101/cshperspect.a011148.

Abstract

cAMP was the first second messenger to be identified. Its three main effectors are PKA (which phosphorylates numerous metabolic enzymes), EPAC (a guanine-nucleotide-exchange factor), and cyclic-nucleotide-gated ion channels.

Publication types

  • Review

MeSH terms

  • 3',5'-Cyclic-AMP Phosphodiesterases / metabolism*
  • Adenylyl Cyclases / metabolism*
  • Animals
  • Cyclic AMP / metabolism*
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Gene Expression Regulation / physiology*
  • Humans
  • Models, Biological
  • Second Messenger Systems / physiology*

Substances

  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases
  • 3',5'-Cyclic-AMP Phosphodiesterases
  • Adenylyl Cyclases