Abstract
cAMP was the first second messenger to be identified. Its three main effectors are PKA (which phosphorylates numerous metabolic enzymes), EPAC (a guanine-nucleotide-exchange factor), and cyclic-nucleotide-gated ion channels.
MeSH terms
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3',5'-Cyclic-AMP Phosphodiesterases / metabolism*
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Adenylyl Cyclases / metabolism*
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Animals
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Cyclic AMP / metabolism*
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Cyclic AMP-Dependent Protein Kinases / metabolism*
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Gene Expression Regulation / physiology*
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Humans
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Models, Biological
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Second Messenger Systems / physiology*
Substances
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Cyclic AMP
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Cyclic AMP-Dependent Protein Kinases
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3',5'-Cyclic-AMP Phosphodiesterases
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Adenylyl Cyclases