Abstract
Nasopharyngeal carcinoma (NPC) is an EBV-associated cancer. We analysed Siah1 expression as well as LMP1 and HIF1α expression by immuno-histochemical staining in 74 NPC biopsy specimens and found that the expression of Siah1 was significantly correlated with advanced tumour status and stage. Moreover, Siah1-positive and HIF1α-positive cases had significantly worse prognoses. The expression score for LMP1 was remarkably correlated with that of Siah1, whereas there was little correlation between LMP1 expression and the other markers evaluated. This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers, Tumor / metabolism*
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Carcinoma
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Carcinoma, Squamous Cell / metabolism*
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Carcinoma, Squamous Cell / mortality
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Carcinoma, Squamous Cell / pathology
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DNA, Viral / analysis
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DNA, Viral / genetics
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
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Immunoenzyme Techniques
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In Situ Hybridization
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Male
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Middle Aged
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Nasopharyngeal Carcinoma
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Nasopharyngeal Neoplasms / metabolism*
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Nasopharyngeal Neoplasms / mortality
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Nasopharyngeal Neoplasms / pathology
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Neoplasm Staging
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Nuclear Proteins / metabolism*
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Polymerase Chain Reaction
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Prognosis
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Survival Rate
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Ubiquitin-Protein Ligases / metabolism*
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Viral Matrix Proteins / metabolism*
Substances
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Biomarkers, Tumor
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DNA, Viral
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EBV-associated membrane antigen, Epstein-Barr virus
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HIF1A protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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Nuclear Proteins
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Viral Matrix Proteins
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Ubiquitin-Protein Ligases
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seven in absentia proteins