Abstract
Telaprevir is a recently approved direct-acting antiviral against hepatitis C virus (HCV) that works through inhibition of the NS3/4A serine protease inhibitor.Phase 2b and 3 studies have shown marked increase in sustained virological response rates in both treatment-naïve and treatment-experienced patients with HCV genotype 1 treated with a telaprevir-containing regimen compared with pegylated interferon (PEG-IFN) and ribavirin alone. The most commonly observed side effects of telaprevir therapy are anaemia to a greater degree than that observed with PEG-IFN/ribavirin alone; eczematous rash, which can be severe in a minority of patients; and anorectal discomfort.
Copyright © 2013 Elsevier Inc.
MeSH terms
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Antiviral Agents / adverse effects
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Antiviral Agents / therapeutic use*
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Carrier Proteins / antagonists & inhibitors
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Carrier Proteins / metabolism
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Drug Therapy, Combination
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Genotype
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Hepacivirus / drug effects*
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Hepacivirus / enzymology
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Hepacivirus / genetics
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Hepatitis C, Chronic / diagnosis
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Hepatitis C, Chronic / drug therapy*
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Humans
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Interferon alpha-2
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Interferon-alpha / therapeutic use
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Intracellular Signaling Peptides and Proteins
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Oligopeptides / adverse effects
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Oligopeptides / therapeutic use*
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Polyethylene Glycols / therapeutic use
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Practice Guidelines as Topic
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Recombinant Proteins / therapeutic use
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Ribavirin / therapeutic use
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Serine Proteinase Inhibitors / adverse effects
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Serine Proteinase Inhibitors / therapeutic use*
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Time Factors
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Treatment Outcome
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Viral Load
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Viral Nonstructural Proteins / antagonists & inhibitors
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Viral Nonstructural Proteins / metabolism
Substances
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Antiviral Agents
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Carrier Proteins
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Interferon alpha-2
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Interferon-alpha
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Intracellular Signaling Peptides and Proteins
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NS3 protein, hepatitis C virus
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NS4A cofactor peptide, Hepatitis C virus
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Oligopeptides
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Recombinant Proteins
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Serine Proteinase Inhibitors
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Viral Nonstructural Proteins
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Polyethylene Glycols
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Ribavirin
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telaprevir
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peginterferon alfa-2b
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peginterferon alfa-2a