Abstract
Cerebral venous thrombosis (CVT) is a rare complication during pregnancy or the puerperium. Our aim was to identify thrombotic risk profiles that predispose to maternal CVT.The study comprised 151 individuals. All participants had a thrombotic workup that included the following: genetic markers: factor V Leiden G1691A and G20210A prothrombin mutations, methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms; protein assays: protein C, protein S and antithrombin; other tests: blood typing and screening for hyperhomocysteinemia. Maternal CVT has been associated with factor V Leiden, the prothrombin G20210A mutation, protein C deficiency and hyperhomocysteinemia. We also speculate that non-O blood groups and preeclampsia could be independent risk factors for CVT.
MeSH terms
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Adult
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Antithrombin III / metabolism
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Biomarkers / blood
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DNA Mutational Analysis
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Factor V / genetics
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Female
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Humans
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Hyperhomocysteinemia / complications
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Hyperhomocysteinemia / genetics*
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Hyperhomocysteinemia / pathology
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Intracranial Thrombosis / complications
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Intracranial Thrombosis / genetics*
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Intracranial Thrombosis / pathology
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Methylenetetrahydrofolate Reductase (NADPH2) / genetics
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Polymorphism, Single Nucleotide*
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Pregnancy
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Pregnancy Complications, Hematologic / genetics*
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Pregnancy Complications, Hematologic / pathology
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Protein C / metabolism
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Protein S / metabolism
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Prothrombin / genetics*
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Risk Factors
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Venous Thrombosis / complications
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Venous Thrombosis / genetics*
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Venous Thrombosis / pathology
Substances
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Biomarkers
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Protein C
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Protein S
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factor V Leiden
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Antithrombin III
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Factor V
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Prothrombin
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MTHFR protein, human
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Methylenetetrahydrofolate Reductase (NADPH2)