Abstract
In 2012, studies of autosomal dominant Alzheimer disease (AD), late-onset AD, and a rare genetic mutation of amyloid precursor protein provided support for the critical role of amyloid in AD pathogenesis. Increasing evidence implicated cell-to-cell transmission in the spread of tau and amyloid, highlighting novel targets for therapeutic intervention.
MeSH terms
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Alzheimer Disease / drug therapy
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Alzheimer Disease / genetics
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Alzheimer Disease / pathology*
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Amyloid beta-Peptides / genetics
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Amyloid beta-Peptides / physiology
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Antibodies, Monoclonal / therapeutic use
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Brain / pathology
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Clinical Trials, Phase III as Topic
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Dementia / genetics
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Dementia / pathology*
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Disease Progression
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Humans
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Mutation / genetics
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Mutation / physiology
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Treatment Failure
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tau Proteins / genetics
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tau Proteins / physiology
Substances
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Amyloid beta-Peptides
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Antibodies, Monoclonal
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tau Proteins