Dementia in 2012: Further insights into Alzheimer disease pathogenesis

Nat Rev Neurol. 2013 Feb;9(2):65-6. doi: 10.1038/nrneurol.2012.275. Epub 2013 Jan 22.

Abstract

In 2012, studies of autosomal dominant Alzheimer disease (AD), late-onset AD, and a rare genetic mutation of amyloid precursor protein provided support for the critical role of amyloid in AD pathogenesis. Increasing evidence implicated cell-to-cell transmission in the spread of tau and amyloid, highlighting novel targets for therapeutic intervention.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / genetics
  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / physiology
  • Antibodies, Monoclonal / therapeutic use
  • Brain / pathology
  • Clinical Trials, Phase III as Topic
  • Dementia / genetics
  • Dementia / pathology*
  • Disease Progression
  • Humans
  • Mutation / genetics
  • Mutation / physiology
  • Treatment Failure
  • tau Proteins / genetics
  • tau Proteins / physiology

Substances

  • Amyloid beta-Peptides
  • Antibodies, Monoclonal
  • tau Proteins