Genetic linkage is excluded for the D2-dopamine receptor lambda HD2G1 and flanking loci on chromosome 11q22-q23 in Tourette syndrome

Hum Hered. 1990;40(2):105-8. doi: 10.1159/000153914.

Abstract

A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2-dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to +/- 20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosomes, Human, Pair 11*
  • DNA Probes
  • Female
  • Genetic Linkage*
  • Humans
  • Lod Score
  • Male
  • Receptors, Dopamine / genetics*
  • Tourette Syndrome / genetics*

Substances

  • DNA Probes
  • Receptors, Dopamine