HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer

Sen Wang; Tianyun Pang; Min Gao; Haixian Kang; Weibin Ding; Xiwen Sun; Yi Zhao; Wei Zhu; Xudong Tang; Yunhong Yao; Xinrong Hu

doi:10.1016/j.febslet.2013.01.042

HPV E6 induces eIF4E transcription to promote the proliferation and migration of cervical cancer

FEBS Lett. 2013 Mar 18;587(6):690-7. doi: 10.1016/j.febslet.2013.01.042. Epub 2013 Feb 11.

Authors

Sen Wang¹, Tianyun Pang, Min Gao, Haixian Kang, Weibin Ding, Xiwen Sun, Yi Zhao, Wei Zhu, Xudong Tang, Yunhong Yao, Xinrong Hu

Affiliation

¹ Cancer Institute of Guangdong Medical College, No 1 Xincheng Road, Dongguan, Guangdong Province 523808, PR China.

PMID: 23410891
DOI: 10.1016/j.febslet.2013.01.042

Abstract

Increasing evidence has placed eukaryotic translation initiation factor 4E (eIF4E) at the hub of tumor development and progression. Several studies have reported that eIF4E is over-expressed in cervical cancer; however, the mechanism remains elusive. The results of this study further confirm over-expression of eIF4E in cervical cancer tumors and cell lines, and we have discovered that the transcription of eIF4E is induced by protein E6 of the human papillomavirus (HPV). Moreover, regulation of eIF4E by E6 significantly influences cell proliferation, the cell cycle, migration, and apoptosis. Therefore, eIF4E emerges as a key player in tumor development and progression and a potential target for CC treatment and prevention.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Carcinoma, Squamous Cell / genetics*
Carcinoma, Squamous Cell / metabolism
Carcinoma, Squamous Cell / pathology
Carcinoma, Squamous Cell / virology
Cell Cycle
Cell Movement
Cell Proliferation
Cervix Uteri / metabolism
Cervix Uteri / pathology
Cervix Uteri / virology
Diffusion Chambers, Culture
Eukaryotic Initiation Factor-4E / genetics*
Eukaryotic Initiation Factor-4E / metabolism
Female
Gene Expression Regulation, Neoplastic*
Humans
Oncogene Proteins, Viral / antagonists & inhibitors
Oncogene Proteins, Viral / genetics*
Oncogene Proteins, Viral / metabolism
Plasmids
RNA, Small Interfering / genetics
Repressor Proteins / antagonists & inhibitors
Repressor Proteins / genetics*
Repressor Proteins / metabolism
Signal Transduction
Transcription, Genetic*
Transfection
Uterine Cervical Dysplasia / genetics*
Uterine Cervical Dysplasia / metabolism
Uterine Cervical Dysplasia / pathology
Uterine Cervical Dysplasia / virology
Uterine Cervical Neoplasms / genetics*
Uterine Cervical Neoplasms / metabolism
Uterine Cervical Neoplasms / pathology
Uterine Cervical Neoplasms / virology

Substances

E6 protein, Human papillomavirus type 16
Eukaryotic Initiation Factor-4E
Oncogene Proteins, Viral
RNA, Small Interfering
Repressor Proteins