Kinetic modeling of metabolic pathways: application to serine biosynthesis

Kieran Smallbone; Natalie J Stanford

doi:10.1007/978-1-62703-299-5_7

Kinetic modeling of metabolic pathways: application to serine biosynthesis

Methods Mol Biol. 2013:985:113-21. doi: 10.1007/978-1-62703-299-5_7.

Authors

Kieran Smallbone¹, Natalie J Stanford

Affiliation

¹ Manchester Centre for Integrative Systems Biology, University of Manchester, Manchester, UK. kieran.smallbone@manchester.ac.uk

PMID: 23417802
DOI: 10.1007/978-1-62703-299-5_7

Abstract

In this chapter, we describe the steps needed to create a kinetic model of a metabolic pathway using kinetic data from both experimental measurements and literature review. Our methodology is presented by using the example of serine biosynthesis in E. coli.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Computational Biology
Escherichia coli / metabolism*
Kinetics
Metabolic Networks and Pathways
Models, Biological*
Serine / biosynthesis*
Software

Substances

Serine