Abstract
Although some evidence has been documented on EGFR/PI3K mediation of Akt activation in breast cancers, ILK and DNA-PK have not been investigated so far. The aim of this study was to analyze the expression of phosphorylated Akt (pAkt) in breast cancer, with respect to its upstream regulators. The immunostaining of pAkt (Ser473) in 70 invasive breast cancers revealed that status of CerbB2 could play a major role in Akt phosphorylation, while ILK was also involved in the stimulated level of pAkt. The results would provide an important clue for the activation of Akt and potential targeted therapy in breast cancer.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Biomarkers, Tumor / metabolism
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Breast Neoplasms / genetics
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Breast Neoplasms / metabolism*
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Breast Neoplasms / pathology
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Carcinoma, Ductal, Breast / genetics
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Carcinoma, Ductal, Breast / metabolism*
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Carcinoma, Ductal, Breast / pathology
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Carcinoma, Intraductal, Noninfiltrating / genetics
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Carcinoma, Intraductal, Noninfiltrating / metabolism*
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Carcinoma, Intraductal, Noninfiltrating / pathology
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DNA-Activated Protein Kinase / metabolism
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Female
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Gene Expression Regulation, Neoplastic*
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Humans
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Immunohistochemistry
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Nuclear Proteins / metabolism
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Phosphorylation
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Protein Serine-Threonine Kinases / metabolism
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Proto-Oncogene Proteins c-akt / genetics
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Proto-Oncogene Proteins c-akt / metabolism*
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Receptor, ErbB-2 / genetics
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Receptor, ErbB-2 / metabolism*
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Retrospective Studies
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Signal Transduction / physiology
Substances
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Biomarkers, Tumor
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Nuclear Proteins
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integrin-linked kinase
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Receptor, ErbB-2
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DNA-Activated Protein Kinase
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PRKDC protein, human
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt