Unsuccessful switch from insulin to sulfonylurea therapy in permanent neonatal diabetes mellitus due to an R201H mutation in the KCNJ11 gene: a case report

Jeong Won Heo; Sang-Wook Kim; Eun-Hee Cho

doi:10.1016/j.diabres.2013.01.016

Unsuccessful switch from insulin to sulfonylurea therapy in permanent neonatal diabetes mellitus due to an R201H mutation in the KCNJ11 gene: a case report

Diabetes Res Clin Pract. 2013 Apr;100(1):e1-2. doi: 10.1016/j.diabres.2013.01.016. Epub 2013 Feb 21.

Authors

Jeong Won Heo¹, Sang-Wook Kim, Eun-Hee Cho

Affiliation

¹ Department of Internal Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, 26 Kangwondaehak-gil, Chuncheon-si, Gangwon-do 200-701, Republic of Korea.

PMID: 23434183
DOI: 10.1016/j.diabres.2013.01.016

Abstract

Mutations in KCNJ11 are a common cause of permanent neonatal diabetes mellitus. Previously, all patients carrying an R201H mutation in the KCNJ11 gene showed successful switches from insulin to sulfonylurea. Here, we report an unsuccessful switch in an 18-year-old patient carrying the common R201H mutation in the KCNJ11 gene.

Publication types

Case Reports

MeSH terms

Administration, Oral
Adolescent
Arginine
Blood Glucose / metabolism
Diabetes Mellitus, Type 1 / blood
Diabetes Mellitus, Type 1 / drug therapy*
Diabetes Mellitus, Type 1 / genetics
Glyburide / therapeutic use*
Glycated Hemoglobin / metabolism
Histidine
Humans
Hypoglycemic Agents / therapeutic use*
Insulin / blood
Insulin / therapeutic use*
Male
Mutation, Missense / genetics*
Potassium Channels, Inwardly Rectifying / blood
Potassium Channels, Inwardly Rectifying / genetics*
Sulfonylurea Compounds / therapeutic use*
Treatment Failure

Substances

Blood Glucose
Glycated Hemoglobin A
Hypoglycemic Agents
Insulin
Kir6.2 channel
Potassium Channels, Inwardly Rectifying
Sulfonylurea Compounds
hemoglobin A1c protein, human
Histidine
Arginine
Glyburide