Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype

Giselle Izzo; Orestes V Forlenza; Bernardo dos Santos; Paulo H F Bertolucci; Elida B Ojopi; Wagner F Gattaz; Daniel Shikanai Kerr

doi:10.6061/clinics/2013(02)rc01

Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype

Clinics (Sao Paulo). 2013;68(2):277-80. doi: 10.6061/clinics/2013(02)rc01.

Authors

Giselle Izzo¹, Orestes V Forlenza, Bernardo dos Santos, Paulo H F Bertolucci, Elida B Ojopi, Wagner F Gattaz, Daniel Shikanai Kerr

Affiliation

¹ Laboratory of Neuroscience, Department and Institute of Psychiatry, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Abstract

In this study, we investigated the associations between single-nucleotide polymorphisms in GAB2 (rs2373115), GSK3B (rs6438552) and SORL1 (rs641120) and Alzheimer's disease (AD), both alone and in combination with the APOE*4 allele.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / genetics*
Age of Onset
Aged
Alzheimer Disease / genetics*
Apolipoprotein E4 / genetics*
Cytoskeletal Proteins / genetics*
Female
Humans
LDL-Receptor Related Proteins / genetics*
Male
Membrane Transport Proteins / genetics*
Nuclear Proteins / genetics*
Polymorphism, Single Nucleotide / genetics*
Risk Factors

Substances

Adaptor Proteins, Signal Transducing
Apolipoprotein E4
Cytoskeletal Proteins
GAB2 protein, human
LDL-Receptor Related Proteins
Membrane Transport Proteins
NIN protein, human
Nuclear Proteins
SORL1 protein, human