Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population

Lingjun Zhu; Mulong Du; Dongying Gu; Lan Ma; Haiyan Chu; Na Tong; Jinfei Chen; Zhengdong Zhang; Meilin Wang

doi:10.1371/journal.pone.0059256

Genetic variant rs7758229 in 6q26-q27 is not associated with colorectal cancer risk in a Chinese population

PLoS One. 2013;8(3):e59256. doi: 10.1371/journal.pone.0059256. Epub 2013 Mar 12.

Authors

Lingjun Zhu¹, Mulong Du, Dongying Gu, Lan Ma, Haiyan Chu, Na Tong, Jinfei Chen, Zhengdong Zhang, Meilin Wang

Affiliation

¹ Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Abstract

Background: A recent genome-wide association study has identified a new genetic variant rs7758229 in SLC22A3 for colorectal cancer susceptibility in a Japanese population, but it is unknown whether this newly identified variant is associated with colorectal cancer in other populations, including the Chinese population.

Methods: We examined the associations between rs7758229 and colorectal cancer risk among 1,147 cases and 1,203 controls matched by age and sex. Logistic regression model was used to assess the associations.

Results: No significant association was found between rs7758229 and colorectal cancer risk (OR = 0.95, 95%CI = 0.84-1.09, P = 0.463). Similar results were observed in the stratification of tumor location (OR = 0.94, 95%CI = 0.80-1.11, P = 0.481 for colon cancer, and OR = 0.96, 95%CI = 0.82-1.13, P = 0.621 for rectum cancer).

Conclusions: Our findings did not support an association between rs7758229 in 6q26-q27 and the risk of colorectal cancer in a Chinese population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / ethnology
Adenocarcinoma / genetics*
Aged
Alleles
Asian People*
Case-Control Studies
Chromosomes, Human, Pair 6*
Colorectal Neoplasms / ethnology
Colorectal Neoplasms / genetics*
Female
Gene Frequency
Genetic Loci
Humans
Male
Middle Aged
Organic Cation Transport Proteins / genetics*
Polymorphism, Single Nucleotide*

Substances

Organic Cation Transport Proteins
solute carrier family 22 (organic cation transporter), member 3

Grants and funding

This study was partly supported by National Natural Science Foundation of China (81201570, 81102089, and 81230068), National Natural Science Foundation of Jiangsu Province (BK2010080 and BK2011773), the Key Program for Basic Research of Jiangsu Provincial Department of Education (11KJB330002), the Qing Lan Project of Jiangsu Provincial Department of Education, and the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.