SLC1A2 variant associated with essential tremor but not Parkinson disease in Chinese subjects

Neurology. 2013 Apr 23;80(17):1618-9. doi: 10.1212/WNL.0b013e31828f1903. Epub 2013 Apr 17.

Abstract

Essential tremor (ET) is characterized by postural and action tremor.(1-3) A genome-wide association study (GWAS) identified a LINGO1 gene variant to be associated with ET.(4) Subsequent GWAS further identified an intronic variant (rs3794087) of the main glial glutamate transporter (SLC1A2) gene to be associated with ET with an odds ratio (OR) of approximately 1.4.(5) We conducted a case-control study to examine the SLC1A2 gene variant in an Asian cohort of ET. In addition, we also investigated the variant in patients with Parkinson disease (PD) because the GWAS LINGO1 variant has been implicated in both ET and PD and etiologic links between the conditions have been suggested.(6.)

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People / genetics
  • Case-Control Studies
  • Essential Tremor / genetics*
  • Excitatory Amino Acid Transporter 2
  • Female
  • Genome-Wide Association Study
  • Glutamate Plasma Membrane Transport Proteins / genetics*
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / genetics*
  • Polymorphism, Single Nucleotide

Substances

  • Excitatory Amino Acid Transporter 2
  • Glutamate Plasma Membrane Transport Proteins
  • SLC1A2 protein, human